Submit Manuscript  

Article Details


Biomarkers of Inflammation and Remodelling in Cystic Fibrosis

[ Vol. 3 , Issue. 2 ]

Author(s):

Massimo Conese, Silvia Amedea Tirelli, Gianfranco Alicandro, Sante Di Gioia, Annalucia Carbone, Stefano Castellani and Carla Colombo   Pages 92 - 108 ( 17 )

Abstract:


Cystic fibrosis (CF) lung disease is nowadays appreciated as a complex trait, characterised by dysfunction of the CF Transmembrane Conductor (CFTR) protein, opportunistic bacterial infections, chronic inflammation and remodelling of the airways. In this review, we have analysed the usefulness of biomarkers of inflammation and remodelling for their ability in predicting and assessing the onset of a pulmonary exacerbation, its evolution with time and its response to therapeutic interventions. Studies concerning sputum, bronchoalveolar lavage fluid, exhaled breath condensate and blood were considered. Our conclusions are: I) although their validity has been proven across different clinical settings, presently there is no biomarker which can be “promoted” to the status of surrogate end-point; II) longitudinal studies at different ages will be needed for assessing this issue; and III) different therapies should consider not only one biomarker but a constellation of them aiding in the evaluation of the complex pathogenesis of CF lung disease.

Keywords:

Bronchoalveolar lavage, cystic fibrosis, cytokines, exhaled breath condensate, growth factors, oxidative stress, sputum.

Affiliation:

Department of Medical and Surgical Sciences, University of Foggia, c/o Ospedali Riuniti, Viale L. Pinto 1, 71122 Foggia, Laboratory of Clinical Pathology and CF Microbiology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Department of Clinical Sciences and Community Health, University of Milan, Milan, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Cystic Fibrosis Centre, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan

Graphical Abstract:



Read Full-Text article