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Macrogols: A Misleading Cause of Drug Hypersensitivity Diagnosis

[ Vol. 4 , Issue. 1 ]


Gianfranco Calogiuri*, Caterina Foti, Maria Beatrice Bilo and Lene Heise Garvey   Pages 9 - 13 ( 5 )


Background: Polyethylene Glycols (PEGs) or macrogols are reputed to be inert and nonimmunogenic substances, however they are reported to induce immediate type hypersensitivity reactions. Due to their widespread use in extensively consumed products as cosmetics and drugs, the attention towards these substances is still low.

Conclusion: Therefore, it may be useful to focus clinician's attention on possible adverse reactions caused by these polymers.


Anaphylaxis, excipients, hypersensitivity, immediate-type reaction, macrogols, polyethylene glycols.


Department of Pneumology and Allergy - Hospital Sacro Cuore di Gesu Gallipoli, Lecce, Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, Bari, Department of Internal Medicine, Allergy Unit, University Hospital Ospedali Riuniti Ancona, Ancona, Danish Anaesthesia Allergy Centre, Allergy Clinic, Copenhagen

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