Marina de Bernard and Mario Milco D’Elios Pages 4 - 5 ( 2 )
Besides regulating the humoral immunity, the B cell activating factor (BAFF) has also a crucial role in promoting pathogenic Th17 cell responses: the activity of the cytokine is manifested in autoimmune disorders but also in the inflammatory disease caused by the bacterium Helicobacter pylori. Thus, current evidence suggests that BAFF antagonism may be efficacious in Th17 cell-driven diseases.
Autoimmune disorders, BAFF, Helicobacter pylori, Sjogren’s syndrome, Th17 response, TNF.
Department of Biology, University of Padua, Padua, Italy., Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.